Endocrine Abstracts

This study investigated risk of cardiovascular (CV) events over a period of up to 5 years in adult patients with chronic hypoparathyroidism treated with recombinant human parathyroid hormone (1–84), rhPTH(1–84), compared with a historical control cohort of patients who did not receive rhPTH(1––84). The rhPTH(1–84)-treated patient cohort was derived from the NCT00732615 (REPLACE), NCT01...

Changes in estimated glomerular filtration rate (eGFR) over 5 years were evaluated in adult patients with chronic hypoparathyroidism. A cohort of patients treated with recombinant human parathyroid hormone (1–84), rhPTH(1–84), was derived from NCT01297309 (RACE) and NCT01199614 (HEXT) clinical trials. A historical control patient cohort with hypoparathyroidism who did not receive rhPTH(1–84) or rhPTH(1&#...

This study evaluated risk of chronic kidney disease (CKD) outcomes over a period of up to 5 years in adult patients with chronic hypoparathyroidism treated with recombinant human parathyroid hormone (1–84), rhPTH(1–84), compared with a historical control cohort of patients who did not receive rhPTH(1–84). The cohort of patients with chronic hypoparathyroidism treated with rhPTH(1–84) was de...

IntroductionPatients with pituitary adenomas undergoing transsphenoidal surgery require pre- and post-surgery examination of pituitary hormones. There is currently no consensus on how to evaluate the adrenal axis post-surgery. The aims of this study were to investigate factors that may predict postoperative adrenal insufficiency (AI) and to investigate the overall effect of transsphenoidal surgery on the pituitary function.Methods<...

Background: Ischemic heart disease (IHD) is one of the leading causes of death worldwide. Thus, there is the necessity to find new therapeutic approaches. Thyroid hormones (TH) have a major impact on cardiac function and even appear to improve the outcome after acute ischemia/reperfusion and in chronic heart failure. Still, TH signaling within the heart is not yet completely understood.Aim: This project aims to investigate the influence of TH receptor al...

Objective: Globally, cancer is one of the leading causes of death. Therefore, identification of risk factors is of paramount interest. Whether thyroid dysfunction is a cancer risk factor is currently being debated. The aim of this study was to evaluate the risk of cancer in patients diagnosed with hypothyroidism.Methods: This is a register-based nationwide cohort study of individuals diagnosed with hypothyroidism referred to Danish hospitals (followed fr...

Objectives: Acute liver failure (ALF) is a rare but life-threatening condition with severe liver dysfunction. In ALF liver regeneration capacity is exceeded due to loss of hepatocyte function. A well-known trigger of ALF is paracetamol (acetaminophen, APAP) intoxication. Unfortunately, based on the poor prognosis and rapidly increasing mortality rate liver transplantation offers the so far only effective therapeutic strategy. Even if the underlying mechanisms of ALF are not ye...

Background: Guidelines in healthcare shall be evidence-based, satisfy patients’ needs and improve patients’ outcomes. We aimed to estimate incremental costs after the introduction of a national guideline for Graves’ disease in Sweden adding the Graves’ Recurrent Events After Therapy (GREAT) score with genetic determinants to predict recurrence, a thyroid nurse, calcium-D-vitamin treatment preoperatively, and thyroid stimulating immunoglobulins.<p class=...

The systemic function of thyroid hormones (TH) is highly dependent on their local action in distinct cell populations. A major target of TH are immune cells, yet knowledge on the effect of TH on immune responses is still incomplete. Within this study we aimed to determine the impact of TH on T cells, key players of immune responses, in more detail. To this end, we analyzed the activation and function of T cells from mice lacking TRα (TRα0/0) or expressing ...

The immune system is a major target of thyroid hormones (TH), as they have been shown to act on innate as well as adaptive immune cells affecting their proliferation, activation and survival. However, the local TH action within the immune system is still poorly understood. To improve our understanding of this interaction, we performed an immunophenotyping of mice at baseline using flow cytometry and ELISA. For this, we focused on mice with TRα or TRβ mutations leadin...